product review

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Doctor’s Best SAMe has the ability to elevate mood and general brain function.  It also helps to relieve joint pain and stiffness.  This product also promotes liver function by way of detoxification.   Doctor’s Best SAMe contains double strength SAMe for some real oomph.

SAMe (S-Adenosyl Methionine) comes from the amino acid methionine and is necessary for the synthesis of hormones and some neurotransmitters.  Although it is used throughout the body, it is particularly important to liver, joints and brain.

SAMe may promote joint function by increasing the production of certain sugar proteins that are the building blocks of connective tissue.  Studies indicate that SAMe increases your ability to get around with less stiffness and pain.

SAMe may promote the production of neurotransmitters which elevate mood and enhance the production of phosphatidylcholine for better neurotransmission.

Doctor’s Best states that they use the best quality Italian SAMe that is available. Apparently this gives you the greatest percentage of active S,S from for each serving. The manufacturer states that the production of SAMe generates 2 isomer forms known as S,S and R,S. The S,S is supposed to be the active form and the R,S form is essentially inactive biologically. Italian SAMe is supposed to have the highest percentage of S,S form available.

Three double-blind clinical trials were carried out in 1976, 1987 and 1990 with Italian SAMe.  All three trials demonstrated significant improvement in mood and neural functions.


  • support bones and joints
  • support liver function and health
  • support mood and happiness


coming soon

User Opinions

Doctor’s Best SAMe has high ratings ranging from 4 to 5 stars.  Consumers say they would recommend it to a friend.  Most report that joint pain was relieved within a few weeks and they had ease of movement.


You can take 1 tablet a day without food.  Make sure not to crush or chew the tablet.  Swallow the tablet whole.


If you are pregnant or breast-feeding, you should not use this product.  Consult with your doctor if in question.  If you are taking antidepressants for bipolar disease or manic depression, you should not take this product without consulting your doctor first.  A few consumers have reported stomach and intestine problems.  Again, talk with your doctor if these side effects occur.

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